1.0
Haemoglobin
g/dL
A healthy man with a blood-cell parachute

Advancing the
Management of
ANAEMIA
IN CHRONIC
KIDNEY DISEASE

An oral HIF-PH inhibitor designed to help improve haemoglobin levels in CKD patients through stimulation of endogenous erythropoietin production.

For use in appropriate patients under medical supervision.

Oral Therapy

Convenient once-daily oral administration

HIF-PH Inhibitor

Targets the underlying cause of anaemia in CKD

CKD Anaemia Management

Improves haemoglobin levels effectively

Dialysis & Non-Dialysis Patients

Designed for a broad range of CKD patients

About Oxemia

Innovating anemia care
for a better tomorrow

Oxemia (Desidustat) is India's 1st oral HIF-PHI approved for the treatment of anemia in adult patients with chronic kidney disease (CKD) on dialysis.

Oxemia Desidustat tablet packs in 100, 50 and 25 milligram strengths
1st

India's 1st oral
alternative to ESA

Proven efficacy in
raising & maintaining Hb

Oral convenience
once-daily dosing

Favorable safety
and tolerability profile

Effective Hb Response

88%

of patients achieved Hb increase >= 1 g/dL

Mean Hb Increase

2.1

g/dL from baseline

Patients Maintained Target Hb

76%

maintained Hb 10-13 g/dL at 24 weeks

Data from Phase III trials in CKD patients on dialysis.

About Anaemia

Understanding
anaemia in
chronic kidney
disease

When kidneys are not working as well as they should, the body may produce fewer red blood cells. Understanding the signs is the first step toward a better conversation.

Kidneys with red blood cells
Haemoglobincarries oxygen
O2Oxygen
HbRed blood cells
CKDKidney health

Lower haemoglobin

CKD may reduce the body’s natural erythropoietin production.

Daily impact

Fatigue and breathlessness can disrupt everyday routines.

Track your Hb

Regular monitoring can help guide the right management approach.

Common symptoms

Notice the signs.
Start the conversation.

Persistent fatigue

Shortness of breath

Difficulty concentrating

Low energy

Doctor discussing anaemia symptoms with a patient

Early awareness. Timely action. Better outcomes.

Partner with your doctor to manage anaemia in CKD.

Dosing Guide

Personalized dosing.
Optimized outcomes.

Oxemia dosing is titrated based on Hb response and CKD stage to help achieve and maintain target Hb with minimal dose adjustments.

Doctor reviewing dosing recommendation with a patient
Doctor Recommendation

Titrate dose gradually to achieve target Hb and avoid rapid increases.

Individualize based on response and tolerability.

1

Select CKD Stage

2

Recommended Starting Dose

Target Hb 10 to 13 grams per decilitre
CKD Stage
25 mg
50 mg
100 mg
Stage 5 ND
Once daily
Once daily
Once daily
3

Titration Flow

Start

Choose starting dose based on CKD stage and Hb level.

Assess

Reassess Hb every 2–4 weeks.

Adjust

Increase or decrease dose by 25 mg increments.

Maintain

Maintain target Hb 10–13 g/dL.

Note: Do not increase the dose more frequently than once every 2 weeks.

Personalized care

Dose tailored to CKD stage and patient response.

Better outcomes

Helps achieve target Hb with minimal adjustments.

Evidence-based approach

Titration guided by Hb levels and clinical response.

Patient focused

Improves safety, tolerability and quality of life.

Safety & Use

Using OXEMIA®
safely and effectively

OXEMIA® (Desidustat) is a prescription-only medicine. The summary below explains how to take it and what to be aware of - it does not replace the advice of your doctor or pharmacist.

Always read the full prescribing information and follow your healthcare professional's instructions.

How to take it

Take as prescribed

Use OXEMIA® in the dose and for the duration advised by your doctor - typically once daily.

Swallow whole

Swallow the tablet whole with water. Do not chew, crush or break it.

On an empty stomach

Take it on an empty stomach, unless your doctor advises otherwise.

If you miss a dose

Take it as soon as you remember. Skip it if your next dose is near - never take a double dose to make up.

Common side effects

Most side effects are mild and tend to settle as your body adjusts to treatment. Tell your doctor if any persist, worsen, or concern you.

Abdominal pain Vomiting Fever Weakness Peripheral swelling (oedema) Headache

Safety advice

Alcohol

Caution

It is not known whether alcohol is safe to consume with OXEMIA®. Please consult your doctor.

Pregnancy

Consult

Safety during pregnancy has not been established. Consult your doctor before use.

Breastfeeding

Consult

Information on use while breastfeeding is not available. Please consult your doctor.

Driving

Usually safe

OXEMIA® does not usually affect your ability to drive.

Kidney disease

Caution

Limited data are available in patients with kidney disease. Use under medical supervision.

Liver disease

Caution

Limited data are available in patients with liver disease. Use under medical supervision.

Store below 30°C

Keep in the original pack, away from heat and moisture, and out of the reach of children.

Prescription only

OXEMIA® is a prescription-only medicine. Use it only on the advice of a registered doctor.

Not habit-forming

OXEMIA® has no known habit-forming potential.

Regular monitoring

Your doctor may order blood tests to check haemoglobin, blood counts and electrolytes such as potassium.

Read the full prescribing information

Composition, indication, dosing, administration, warnings and storage in one document.

Clinical Trials & Evidence

Evidence that
empowers confidence

Robust clinical data from Phase III trials demonstrate the efficacy and safety of Desidustat in CKD patients on dialysis.

Phase III trial data

Proven Hb improvement

Well tolerated safety profile

Published in peer-reviewed journals

Mean Hb Change Over Time

14121086WeeksHb (g/dL)
DesidustatEpoetin Alfa
Data from Phase III trials in CKD patients on dialysis.

Patients Achieving Target Hb
(10–13 g/dL) at 24 Weeks

1007550250
79%

Desidustat
(n=348)

58%

Epoetin Alfa
(n=347)

Publications

Indian Journal of Nephrology

Desidustat in non-dialysis CKD patients: A randomized study

2022;32(4):323–330

Journal of Clinical and Diagnostic Research

Efficacy and safety of desidustat in dialysis patients

2022;16(8):OC01–OC05

Nephrology Dialysis Transplantation

HIF-PHI therapy: A new era in anaemia management

2021;36(3):405–413

FAQs

Frequently Asked Questions

Clear answers.
Better conversations.

Find practical information about OXEMIA®, Desidustat, and anaemia management in CKD.

This information does not replace advice from your healthcare professional.

OXEMIA® contains Desidustat, an oral HIF-PH inhibitor developed for the management of anaemia associated with chronic kidney disease.

Still have a question?

Our medical information team is here to help.

Contact

We're here
to help.

For product information, prescribing resources, or medical enquiries, connect with the appropriate Oxemia team.

Call us1800 123 4567

Emailmedical.info@oxemia.com

OfficeZydus Lifesciences Ltd., Ahmedabad, India

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